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Letters in Organic Chemistry

Author(s): S. Collina, D. Rossi, M. Urbano, A. Carnevale Baraglia and O. Azzolina

DOI: 10.2174/157017807781467650

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Microwave and Polymer Assisted Synthesis of a Small Library of α ,β -Unsaturated Methyl Esters via the Wittig Reaction

Page: [384 - 387] Pages: 4

  • * (Excluding Mailing and Handling)

Abstract

An efficient protocol based on the combination of microwave dielectric heating and PASP synthesis using the Wittig reaction was developed and applied to the preparation of α,β-unsaturated methyl esters, key intermediates of new sigma ligands. The stereochemistry of the products was also investigated showing a high E:Z isomeric ratio.

Keywords: Wittig reaction, MAOS, PASPS, sigma ligands intermediates, E:Z isomeric ratio