Author(s): Tuomo A. Keinanen, Aki Jarvinen, Anne Uimari, Jouko Vepsalainen, Alex R. Khomutov, Nikolay A. Grigorenko, Mervi T. Hyvonen, Marc Cerrada-Gimenez, Leena Alhonen and Juhani Janne
Page: [813 - 820] Pages: 8
* (Excluding Mailing and Handling)
We describe synthesis of α-methylated analogues of the natural polyamines and their use as tools in unraveling polyamine functions. Experiments with α-methylated spermidine and spermine revealed that the polyamines are exchangeable in supporting cellular growth. Degradation of the analogues by polyamine oxidase disclosed hidden, aldehydeguided stereospecificity of the enzyme.
Keywords: Hypusine, liver regeneration, pancreatitis, polyamine oxidase, spermidine/spermine N1-acetyltransferase, stereospecificity, transgenic
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