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Letters in Organic Chemistry

Author(s): Daniele Vaccari, Paolo Davoli, Maria Bucciarelli, Alberto Spaggiari and Fabio Prati

DOI: 10.2174/157017807781212157

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A Mild Synthesis of Nitriles by TPPX2-promoted Dehydration of Primary Amides

Page: [319 - 321] Pages: 3

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Abstract

An expeditious route to nitriles via dehydration of primary amides using halotriphenoxy phosphonium halides (TPPX2, X = Cl or Br) is described. The reaction proceeds under very mild conditions and allows the preparation of aromatic and aliphatic nitriles in good to excellent yields.

Keywords: Dehydration, dehydrohalogenation, halotriphenoxy phosphonium halides, imidoyl halides, nitriles, phosphonium salts