Abstract

Synthesis of oxepin-annulated quinolone heterocycles by the combination of Claisen rearrangement, the ringclosing metathesis and Diels-Alder reaction is described. The RCM or RCEM proceeded smoothly in the presence of Grubbs first generation catalyst at room temperature under nitrogen atmosphere.

Keywords: Claisen rearrangement, ring-closing metathesis, enyne metathesis, oxepine, oxacine, Diels-Alder reaction, quinolone derivatives