Author(s): T. Takahashi, H. Shimizu, H. Morimatsu, K. Inoue, R. Akagi, K. Morita, S. Sassa, T. Takahashi, H. Shimizu, H. Morimatsu, K. Inoue, R. Akagi, K. Morita and S. Sassa
Page: [745 - 753] Pages: 9
* (Excluding Mailing and Handling)
Free heme contributes as a major threat to the oxidative tissue injuries because it catalyzes the formation of reactive oxygen species. When free heme concentration is increased, it results in the induction of heme oxygenase-1 (HO- 1), which then breaks free heme down. As such, HO-1 plays a pivotal role in the protection of tissues from oxidative injuries.
Keywords: Carbon monoxide, heme, heme oxygenase-1, inflammation, liver injury, oxidative stress, renal injury, sepsis
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