Mini-Reviews in Medicinal Chemistry

Author(s): Seiichiro Ogawa, Miki Kanto, Yoshiyuki Suzuki, Seiichiro Ogawa, Miki Kanto and Yoshiyuki Suzuki

DOI: 10.2174/138955707781024508

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Development and Medical Application of Unsaturated Carbaglycosylamine Glycosidase Inhibitors

Page: [679 - 691] Pages: 13

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Abstract

This article reviews synthesis and structures of carbaglycosylamines, a group of carbocyclic sugar analogues. Some unsaturated derivatives are known to be potent glycosidase inhibitors. Among them, N-octyl-4-epi-??-valienamine as a lysosomal ??-galactosidase inhibitor is currently undergoing a new molecular therapeutic trial (chemical chaperone therapy) for control of the human ??-galactosidase deficiency disorder, GM1-gangliosidosis.

Keywords: Carbasugars, aminocyclitols, 5a-carbaglycosylamines, glycosidase inhibitors, chemical chaperone therapy, lysosomal disease, GM1-gangliosidosis