The influence of substituents on the yields of the synthesis of seven catechines analogues has been studied. 3-Flavene formation is favoured by electron donors substituents on the A and B rings. Yields of the hydroboration reaction are increased by electron donor substituents on the A ring, while substituents on the B ring do not affect the reaction outcome.
Keywords: Gallocatechin, catechins, total synthesis, structure-reactivity study, EGCG