Letters in Organic Chemistry

Author(s): Nadia Vaiana, Luca Rizzi, Maria G. Pezzano, Roberto Restelli, Filippo Rota, Silvia Stefanini, Silvia Vicentini and Sergio Romeo

DOI: 10.2174/157017807781024291

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Synthesis of Gallocatechin-3-Gallate Analogues

Page: [288 - 291] Pages: 4

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Abstract

The influence of substituents on the yields of the synthesis of seven catechines analogues has been studied. 3-Flavene formation is favoured by electron donors substituents on the A and B rings. Yields of the hydroboration reaction are increased by electron donor substituents on the A ring, while substituents on the B ring do not affect the reaction outcome.

Keywords: Gallocatechin, catechins, total synthesis, structure-reactivity study, EGCG