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Protein & Peptide Letters

Author(s): Meng Li, Wei Han, Quiyang Zhang, Xiaochang Xue, Zenglu Wang and Yingqi Zhang

DOI: 10.2174/092986607780989958

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Development of a Mimotope-Based Vaccine Against CD20 Antigen

Page: [610 - 614] Pages: 5

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Abstract

CD20, a B-cell-specific protein, is a primary target for immunotherapy of B-cell lymphomas. We used a mimotopes of CD20 to construct vaccines for B-cell-related disorders. The immunogenicity of the vaccines was tested in BALB/c mice. Results of this study suggest that the mimotope may be a useful tool for the construction of a functional vaccine to treat B cell-related disorders.

Keywords: CD20, mimotope, vaccine, B-cell lymphoma, immunotherapy, keyhole limpet hemocyanin (KLH)