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Mini-Reviews in Medicinal Chemistry

Author(s): Joseph Markowitz, Alexander D. MacKerell and David J. Weber

DOI: 10.2174/138955707780859422

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A Search for Inhibitors of S100B, a Member of the S100 Family of Calcium-Binding Proteins

Page: [609 - 616] Pages: 8

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Abstract

Typically, malignant melanoma has wild-type p53, and yet this cancer proliferates. S100B, which binds p53 and is up-regulated in melanoma, down-regulates wild-type p53 tumor suppressor function. Inhibitors of the S100B-p53 interaction were identified using computer aided drug design (CADD) combined with NMR methodologies and represent potentially new chemotherapeutics for melanoma.

Keywords: S100B, p53, calcium, inhibitors, drug design, cancer