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Protein & Peptide Letters

Author(s): R. B.V. Horton, S. A.S. Laversin, S. P. Reeder, R. C. Rees and S. E.B. McArdle

DOI: 10.2174/092986607780782768

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Identification of Immunogenic MHC Class II Tyrosinase-Derived Peptides Using HLA-DR1 and HLA-DR4 Transgenic Mice

Page: [455 - 460] Pages: 6

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Abstract

The immunogenicity of “novel” MART-1 and Tyrosinase class-II peptides was assessed in transgenic mice. Tyrosinase141-161 peptide was found to be immunogenic and endogenously processed in the HLA-DRβ1*0101 and HLADR β1*0401 transgenic mice with peptide specific production of IFNγ or IL-5 respectively. The MART-129-43 peptide was only found immunogenic in HLA-DRβ1*0101 mice.

Keywords: mhc class, peptides, cd t cells, vitamin e, dendritic cells