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Letters in Organic Chemistry

Author(s): S. B. Aliabiev, I. S. Ivanov, A. P. Ilyin, D. V. Kravchenko and A. V. Ivachtchenko

DOI: 10.2174/157017807780737318

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Synthesis of Novel 5,6,7-Substituted 3-Phenyl-6,7-Dihydroisoxazolo[4,5-d]Pyrimidines

Page: [203 - 211] Pages: 9

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Abstract

In this work we present a convenient synthetic route to novel 5,6,7-substituted 3-phenyl-6,7-dihydroisoxazolo[ 4,5-d]pyrimidines. The key synthetic step is based on the cyclization of 4-amino-3- phenylisoxazole-5-carboxamides and ethyl 4-[(ethoxymethylene)amino]-3-phenylisoxazole-5-carboxylates. The developed methodology can be easily adapted to high-throughput combinatorial format.

Keywords: Cyclization, heterocycle, isoxazolo[4,5-d]pyrimidine, amines, carboxamides, library