New BINOL Schiff Base as a Tridentate Ligand for Catalytic Asymmetric Addition of Diethylzinc to Aldehydes in the Presence of Titanium Tetraisopropoxide

Bing      Liu; Cao      Fang; Zhi-Bing      Dong; Jin-Shan      Li

Letters in Organic Chemistry

Author(s): Bing Liu, Cao Fang, Zhi-Bing Dong and Jin-Shan Li

DOI: 10.2174/157017807780737327

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New BINOL Schiff Base as a Tridentate Ligand for Catalytic Asymmetric Addition of Diethylzinc to Aldehydes in the Presence of Titanium Tetraisopropoxide

Page: [172 - 174] Pages: 3

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Abstract

We have developed three new chiral 3-substituted BINOL Schiff base ligands for the asymmetric diethylzinc addition to aldehydes in the presence of titanium tetraisopropoxide. The reaction provided optically active second alcohols in high yield and moderate enantioselectivity (up to 67% ee).

Keywords: BINOL, Schiff base, diethylzinc, asymmetric addition, titanium

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