Letters in Organic Chemistry

Author(s): Gabriel O. de Resende, Lucia C. S. Aguiar, Bruno A. Cotrim, Joao F. C. da Silva and O. A. C.Antunes

DOI: 10.2174/157017807780737200

Synthesis of Asymmetric Peptide Mimetic Compounds Containing Tartaric Acid Core. Potential Inhibitors of HIV-1 Protease

Page: [168 - 171] Pages: 4

  • * (Excluding Mailing and Handling)

Abstract

Dihydroxyethylene containing compounds, envisaged as aspartic protease inhibitors (cores), were easily synthesized in few steps, by a sequence involving ring opening of diacetyl tartaric anhydride, peptide coupling and de-esterification under basic conditions affording the desired diols in a simple and inexpensive method.

Keywords: HIV-Protease, inhibitor, dihydroxyethylene, diacetyl tartaric anhydride, ring opening, peptide, mimetic