Mini-Reviews in Medicinal Chemistry

Author(s): S. Rekhraj, J. Kinross, S. Prabhudesai, A. Darzi and P. Ziprin

DOI: 10.2174/138955707780619644

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Intraperitoneal Chemotherapy as First-Line Treatment in the Management of Epithelial Ovarian Cancer

Page: [511 - 519] Pages: 9

  • * (Excluding Mailing and Handling)

Abstract

Recent evidence has suggested improved outcomes following incorporation of intraperitoneal chemotherapy administration with intravenous systemic chemotherapy as first-line treatment of small volume residual epithelial ovarian cancer. This review focuses on the mechanism of actions of the chemotherapeutic drugs and reviews the possible reasons for the superior outcomes of intraperitoneal chemotherapy.

Keywords: Intraperitoneal chemotherapy, cisplatin, carboplatin, paclitaxel, ovarian cancer management