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Letters in Organic Chemistry

Author(s): Weibo Cai, Joseph P. Taulane, Nohemy A. Sorto, Asmik Oganesyan, Carlos G. Gutierrez and Murray Goodman

DOI: 10.2174/157017807780414163

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Scaffold Assembly of Collagen-Like Triple Helices at the C-Terminus

Page: [96 - 101] Pages: 6

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Abstract

Here, we report the C-terminal scaffold assembly of triple helical collagen mimetics using a triserine lactone (TSL) scaffold. It was found that the TSL scaffold can promote the triple helix formation and enhance the thermal stability of the resulting collagen-like structures.

Keywords: Scaffold-assembled collagen mimetics, Triserine lactone, Triple helix, Collagen, Circular dichroism, Thermal denaturation