Abstract

A new synthetic approach to 3-aryl isoquinolines, based on the Pd-catalyzed Suzuki cross-coupling reaction, is reported. The described procedure represents an efficient method to prepare 3-aryl isoquinolines by reaction of a preformed 3-chloro isoquinoline with a phenylboronic acid, especially when the nitrogen atom is positively charged.

Keywords: Suzuki cross-coupling, Pd catalysis, 3-aryl isoquinolines