Abstract

A real continuous-flow process for synthesis of alkyl bromides or cyanides was demonstrated by nucleophilic substitution reactions of tosylates with bromide and/or cyanide conducted in ionic liquid 1- ethyl-3-methylimidazolium tosylate. The process provides higher yields and shorter reaction time and is easily upgraded to large scale.

Keywords: Continuous-flow process, ionic liquid, nucleophilic substitution reaction, distillation, alkyl bromide, alkyl cyanide