Abstract

myo-Inositol monophosphatase has long been a target for drug discovery. Recent work has given detailed insight into its mechanism and dynamics plus new activities and some novel series of inhibitors. The goal of a bio-available inhibitor for this enzyme, however, remains a major challenge for medicinal chemistry.

Keywords: diacylglycerol, G-protein coupled receptor, Lithitum, myo-Inositol 1-phosphate, Circular dichroism, Zinc ion