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Letters in Organic Chemistry

Author(s): Jose C. Barros, Joaquim F. M. da Silva, Alexandre R. Calazans, Amilcar Tanuri, Rodrigo de Morais Brindeiro, John S. Williamson and Octavio A.C. Antunes

DOI: 10.2174/157017806779468040

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Synthesis of Pseudopeptides Derived from (R,R)-Tartaric Acid as Potential Inhibitors of HIV-Protease

Page: [882 - 886] Pages: 5

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Abstract

New pseudopeptides possessing C2 symmetry and dihydroxyethylene core derived from (R,R)- tartaric acid and amino esters have been synthesized as potential inhibitors of HIV protease. The amino esters were chosen in order to interact with P1/P1 and P2/P2 subsites of the enzyme. The products were obtained in good yields without noticeable racemization.

Keywords: AIDS, HIV, tartaric acid, C2 symmetry, protease inhibitors, pseudopeptides