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Protein & Peptide Letters

Author(s): Akikazu Sakudo, Izuru Nakamura, Deug-Chan Lee, Keiichi Saeki, Kazuyoshi Ikuta and Takashi Onodera

DOI: 10.2174/0929866510707010001

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Neurotoxic Prion Protein (PrP) Fragment 106-126 Requires the N-terminal Half of the Hydrophobic Region of PrP in the PrP-Deficient Neuronal Cell Line

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Abstract

The cytotoxicity of aged PrP(106-126) was examined using an immortalized prion protein (PrP) gene-deficient neuronal cell line. The N-terminal half of the hydrophobic region (HR) but not the octapeptide repeat (OR) of PrP was required for aged PrP(106-126) neurotoxicity, suggesting that neurotoxic signals of aged PrP(106-126) are mediated by this region.

Keywords: Prion disease, prion protein (PrP), apoptosis, PrP-deficient cell line, PrP(106-126)