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Protein & Peptide Letters

Author(s): Xing Sheng Wang, Dong Liang Wang, Jing Zhao, Mei Hua Qu, Xiao Hong Zhou, Hai Jin He and Rong Qiao He

DOI: 10.2174/092986606777790566

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The Proline-Rich Domain and the Microtubule Binding Domain of Protein Tau Acting as RNA Binding Domains

Page: [679 - 685] Pages: 7

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Abstract

Neuronal tau, through its proline-rich domain and the microtubule binding domain, binds to RNA nonsequence- specifically via electrostatic interaction. This binding inhibits the activity of tau. Tau and RNA were also found to co-localize in SH-SY5Y cells suggesting that RNA has opportunities to interact with tau in cells.

Keywords: Neuronal tau, RNA, non-sequence-specific RNA-binding, electrostatic interaction, proline rich domain, microtubule binding domain