Diastereoselective Addition of Organolithium to Ferrocene-Carboxaldehyde Imines Derived from (R)- and (S)-1-Phenylethylamine: The Effect of External Additives

Hui-Qing      Zhang; Zhi-Ming      Zhou; Min      Fang

Letters in Organic Chemistry

Author(s): Hui-Qing Zhang, Zhi-Ming Zhou and Min Fang

DOI: 10.2174/157017806779117085

Download PDF Flyer Cite As

Diastereoselective Addition of Organolithium to Ferrocene-Carboxaldehyde Imines Derived from (R)- and (S)-1-Phenylethylamine: The Effect of External Additives

Page: [802 - 805] Pages: 4

* (Excluding Mailing and Handling)

Explore Articles

About Journal

For Authors

For Editors

For Reviewers

Abstract

An efficient and flexible asymmetric synthesis of chiral ferrocenylamines 3a-c via diastereoselective addition of organolithium compounds to chiral imines is described. High diastereoselectivity(93% de) was observed with ferrocenecarboxaldehyde imine 2b in the presence of the Lewis acids BF3oOEt2.

Keywords: Ferrocene, optically active amines, ferrocenecarboxaldehyde imine, asymmetric addition, organolithium, compounds, chiral synthesis

Cite As