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Letters in Organic Chemistry

Author(s): Pietro Campaner, Gian Maria Bonora and Sara Drioli

DOI: 10.2174/157017806779025942

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An Efficient and Selective End-Modification of High-Molecular Weight Poly(Ethylene Glycol)s

Page: [773 - 779] Pages: 7

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Abstract

An innovative procedure aimed to the production of orthogonally protected amino-derivatives of high-molecular weight poly(ethylene glycol) (PEG) modified with linkers bearing differently reactive terminal amino groups is reported. This polymeric derivative represents a convenient, new soluble support particularly suitable as a drug delivery system of mixed molecules.

Keywords: Poly(ethylene glycol), PEG, polymer, conjugates, peptide, drug delivery