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Letters in Organic Chemistry

Author(s): Yoshinobu Tagawa, Kenji Yamagata and Kunihiro Sumoto

DOI: 10.2174/157017806779025951

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Synthesis of Pyrido[3,2-c]coumarin Derivatives by an Intramolecular Cyclization of 4-Methyl-2-(ortho-methoxyphenyl)nicotinic Acid Using Eatons Reagent

Page: [759 - 763] Pages: 5

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Abstract

The reaction of 4-methyl-2-(methoxyphenyl)nicotinic acid with Eatons reagent (P2O5 - CH3SO3H) affords pyrido[3,2-c]coumarin derivatives or 1-methyl-4-azafluoren-9-ones depending on the position of the methoxy group on the benzene ring.

Keywords: Pyrido[3,2-c]coumarin, Eaton's reagent, methoxy group, 1-methyl-4-azafluoren-9-one, intramolecular cyclization