Abstract

A facile synthesis of the title compound has been developed starting from the crotylated product of (R)-cyclohexylideneglyceraldehyde (2). The key features of the synthesis were stereochemical control of the crotylation by alteration of reaction conditions, operational simplicity and the use of inexpensive compounds/reagents.

Keywords: Asymmetric synthesis, (R)-cyclohexylideneglyceraldehyde, hapalosin, β-hydroxy acid