Abstract

Amyloid β-protein (Aβ) plays a pivotal role in Alzheimers disease (AD). Therapeutic strategies inhibiting Aβ aggregation and promoting extracellular Aβ removal are currently advocated. Here, we review recent literature on intracellular Aβ, especially intranuclear Aβ, and its associated molecules. We also discuss alternative therapeutic strategies to inhibit intracellular Aβ-related pathogenesis.

Keywords: Alzheimer's disease, amyloid β-protein, intracellular, intranuclear, Aβ-related Death Inducing Protein, p53, promoter, apoptosis, amyloid -protein, related Death Inducing Protein