Current Topics in Medicinal Chemistry

Author(s): Karen Scalzo, Magdalena Plebanski and Vasso Apostolopoulos

DOI: 10.2174/156802606778194262

Regulatory T-Cells: Immunomodulators in Health and Disease

Page: [1759 - 1768] Pages: 10

  • * (Excluding Mailing and Handling)

Abstract

Regulation of immune responses is crucial in order to maintain immunological self-tolerance. This is maintained in the periphery by a number of cell types that have the capacity to control and regulate immune responses, thus preventing reactivity to self while monitoring appropriate, non-exuberant responses to non-self-antigens. The various mechanisms of regulation will be discussed in this review together with how this knowledge could be used to develop better drugs and treatments for various diseases.

Keywords: CD4+CD25+ regulatory cells, Tr1, Th3, immuno-modulatory drugs