Abstract

Simple and efficient methods have been developed for the synthesis of orthogonally protected 2,5- diaminocyclohexanecarboxylic acid diastereomers via the stereocontrolled transformation of 2-benzyloxycarbonylamino-4-cyclohexenecarboxylic acid to its iodolactone or epoxide.

Keywords: orthogonal protection, β-peptides, β-amino acids, Diaminocarboxylic acids