Abstract

A direct synthesis of substituted oxepin and spiroheterocycles has been achieved from substrates derived from 4-hydroxy-1,6-dimethyl pyridine-2-ones (1) by combining Claisen rearrangement and ring closing enyne metathesis. The RCEM proceeded smoothly under nitrogen atmosphere at room temperature in the presence of well-defined ruthenium catalyst A (10 mol%).

Keywords: 2-Pyridone, oxepin, ring-closing metathesis, Claisen rearrangement, enyne metathesis