Abstract

New types of ribosyl-diazepanone derivatives of nucleoside antibiotic liposidomycins, 12a and 12b, have been synthesised. The ribosyl 7-membered heterocycles were formed by reductive amination of the α-ribosylamino acid 9 derived from D-ribose and the amino aldehydes 10a or 10b, followed by a peptidic coupling reaction.

Keywords: ribosylamino acid, liposidomycin, lactamisation, diazepanone, Antibiotic