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Letters in Organic Chemistry

Author(s): Matar Seck, Blandine Seon-Meniel, Jean-Christophe Jullian, Xavier Franck, Reynald Hocquemiller and Bruno Figadere

DOI: 10.2174/157017806776611818

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Synthesis of C1-C6 Fragment of Caribenolide I

Page: [390 - 395] Pages: 6

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Abstract

Stereoselective synthesis of C1-C6 fragment of caribenolide I, a potent antitumour macrolide isolated from a marine dinoflagellate Amphidinium sp. is described. The key step relies on an asymmetric aldol reaction for control the absolute configurations of C2 and C3 stereogenic centers (caribenolide I numbering).

Keywords: Amphidinolide, macrolide, antitumor, cytotoxic activity, aldolisation, oxazolidinones, oxazolidin-2-thiones