Author(s): Pierre Renard, Daniel-Henri Caignard, Catherine Dacquet, Jean Boutin, Pascale Chomarat, Valerie Audinot-Bouchez, Rene Gree, Paul Mosset and Frederic Caijo
Page: [103 - 106] Pages: 4
* (Excluding Mailing and Handling)
The total synthesis of a 2,3-disubstituted benzofuran, designed as a structural analogue of a bioactive arachidonic acid metabolite, the 8-(S)-HETE, is reported. This heterocyclic derivative has been evaluated as dual agonist of the PPARα and PPARγ nuclear receptors.
Keywords: 8-HETE, benzofuran, PPARs
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