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Protein & Peptide Letters

Author(s): Frederick Harris, Sarah Dennison and David A Phoenix

DOI: 10.2174/092986606777145832

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The Prediction of Hydrophobicity Gradients within Membrane Interactive Protein α-Helices Using a Novel Graphical Technique

Page: [595 - 600] Pages: 6

  • * (Excluding Mailing and Handling)

Abstract

Here, it is shown that amphiphilicity profiling based on the mean hydrophobic moment provides a simple visual guide for the identification of oblique orientated a-helices. The methodology has an efficiency of circa 70% and predicts that approximately 40% of transmembrane a-helices may possess these structures.

Keywords: Oblique orientated α-helix, hydrophobicity gradient, hydropathy plot analysis, hydrophobic moment, amphiphilic profiling, transmembrane protein