Abstract

HIV-1 reverse transcriptase-associated ribonuclease H (RNase H) is an attractive non traditional target for drug development which has been, so far, little explored. All drugs shown to inhibit HIV-1 RNase H are reported, including the recently described classes of compounds that interact with the metal ions in the active site.

Keywords: HIV-1, Reverse transcriptase, Ribonuclease H, Inhibition, Drug development, N-hydroxyimides, Diketo acids