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Cardiovascular & Hematological Disorders-Drug Targets

Author(s): Sonia Laneri, Cristina Di Ronza, Antonietta Bernardi, Carmine Ostacolo, Antonia Sacchi, Carmela Cervone, Michele D'Amico, Clara Di Filippo, Maria Letizia Trincavelli, Anna Panighini and Claudia Martini

DOI: 10.2174/187152911798347016

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Synthesis and Antihypertensive Action of New Imidazo[1,2-a]pyridine Derivatives , non Peptidic Angiotensin II Receptor Antagonists

Page: [87 - 96] Pages: 10

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Abstract

The synthesis and antihypertensive activity of a group of imidazo[1,2-a]pyridine is described. New synthesized compound have been tested both in vivo and in vitro as antagonists on Angiotensin AT1 receptor, and compared to Losartan, used as reference drug. Binding assay an Angiotensin AT1 receptor were carried on as well. Compounds 6b and 6g showed a potent antihypertensive activity and an high affinity on AT1 receptor.

Keywords: AngII AT1 receptor antagonists, antihypertensive in vivo and in vitro activity, imidazo[1,2-a]pyridine, Synthesis and Antihypertensive Action of New Imidazo[1,2-a]pyridine Derivatives, non Peptidic Angiotensin II Receptor, Antagonists, linear octapeptide angiotensin