Abstract

Asymmetric Mannich-type reactions are important organic transformations that provide excellent protocols for the synthesis of optically active nitrogen-containing compounds. This article provides an overview on the development of thiourea-catalyzed asymmetric Mannich or nitro-Mannich reactions including scope, limitations, and applications of different catalytic systems.

Keywords: Thiourea, Mannich-type reaction, asymmetric catalysis, organocatalysis, organocatalytic, organic chemistry, stereoselective catalysis, hydrogen-bonding donors, monothiourea, bis-thiourea, b-amino acids, Lewis basic, Isoquinolines, Wittig Reaction, Nitro-Mannich