Abstract

Phosphines have recently become popular choices as nucleophilic catalysts in many asymmetric reactions, including: diastereoselective reactions, enantioselective reactions and other special type asymmetric reactions, such as kinetic resolution and desymmetrization. This mini-review presents recent advances in the application of nucleophilic phosphine organocatalysts for the preparation of chiral building blocks.

Keywords: Desymmetrization, diastereoselective reaction, enantioselective reaction, kinetic resolution, organocatalysis, phosphine, Nucleophilic Tertiary, Asymmetric Reactions, selectivity of enzymes, enantioselective reactions, Aza-Morita-Baylis-Hillman Reaction, C-C bond-forming reaction, homologues, medicinally relevant compounds, natural products