Author(s): Daisuke Iyaguchi, Min Yao, Nobuhisa Watanabe, Jun Nishihira and Isao Tanaka
Page: [531 - 533] Pages: 3
* (Excluding Mailing and Handling)
Hepatocyte nuclear factor 6 (HNF-6)/OC-1, a part of liver-enriched transcription factor, controls pancreas and liver development and regulates expression of several hepatic genes. DNA-binding region of HNF-6α bound to a 14-mer DNA fragment has been crystallized by the hanging drop vapor diffusion method. The crystals belong to space group P2 with unit cell parameters of a = 73.0 Å, b = 39.0 Å, c = 106.5 Å, β= 107.6 . X-ray diffraction data were collected to 2.0 Å resolution.
Keywords: HNF-6, Transcription regulator, Homeobox, ONECUT, Crystallization
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