Mini-Reviews in Medicinal Chemistry

Author(s): David Vidal

DOI: 10.2174/138955706776876131

Topical Imiquimod: Mechanism of Action and Clinical Applications

Page: [499 - 503] Pages: 5

  • * (Excluding Mailing and Handling)

Abstract

Imiquimod is a synthetic imidazoquinoline heterocyclic amine of 240.3 Da (C14H16N4). Imiquimod is a cytokine inducer and a modifier of the innate immune response, as well as acquired antiviral and antitumor immune responses. Imiquimod 5% cream has proven to be an effective treatment for external genital warts, superficial basal cell carcinoma, and actinic keratosis.

Keywords: Imiquimod, imidazoquinolone, immune response modifier, toll-like receptor, skin infection, skin cancer