Abstract

Recent progress in understanding of the nitric oxide and cGMP signaling pathway provided evidence for mechanism of action of known drugs and identified novel targets for drug development. These discoveries resulted in numerous efforts in drug and formulation discovery. Some of the most promising approaches were applied for efficient therapies of various diseases.

Keywords: Nitric oxide, cGMP, nitric oxide synthase, guanylyl cyclase, phosphodiesterase, traditional Chinese medicine, drug development, numerous efforts, drug and formulation discovery, promising approaches