Abstract

Lewis and Bronsted base catalysis are rapidly growing areas in organocatalysis. Numerous binaphthyl-derived chiral base catalysts has been developed over the last years. Recent progress in the chiral Lewis and Bronsted base catalysis has been reviewed with a focus being placed on mono-functional catalysts, including primary and secondary diamines, guanidines, phosphines and phosphineoxides; bi- and multifunctional catalysts, covering secondary and/or tertiary amine and phosphine derivatives assisted with urea/thiourea hydrogen bond donors or Lewis/ Bronsted acids.

Keywords: Asymmetric organocatalysis, bi-/multi-functional catalysis, binaphthyl-derived organocatalysts, Bronsted bases, Lewis bases, urea/thioureas, Primary Diamines, Guanidine Derivatives, Secondary Diamines, Chiral Phosphineoxides, Alcohol-Assisted Tertiary Amines, B- OR LI-BINOL COMPLEXES, phase transfer catalysts (PTC), tetramethylguanidine (TMG), chemoselective