Current Organic Synthesis

Author(s): Jing Song, Houcheng Zhang, Lei Li, Zishu Bi, Min Chen, Wei Wang, Qingjia Yao, Hongjie Guo, Min Tian, Hanfen Li, Wen Yi and Peng George Wang

DOI: 10.2174/157017906776819187

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Enzymatic Biosynthesis of Oligosaccharides and Glycoconjugates

Page: [159 - 168] Pages: 10

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Abstract

Natural carbohydrates have complex structures including many kinds of monosaccharide units, which are very difficult and costly to generate by chemical synthetic approaches. Over the years, enzymatic approaches have been gaining popularity for the synthesis of oligosaccharides and glycoconjugates, and it is becoming increasingly feasible to produce complex carbohydrates in large scale, following enzymatic biosynthetic pathways.

Keywords: Glycosidases, sugar nucleotides, glycosyl donors, UDP, , N -acetylglucosamine, Glycosyltransferases