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Protein & Peptide Letters

Author(s): J. M. Conlon, Nadia Al-Ghaferi, Bency Abraham, Agnes Sonnevend, Jay D. King and Per F. Nielsen

DOI: 10.2174/092986606775974410

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Purification and Properties of Laticeptin, an Antimicrobial Peptide from Skin Secretions of the South American Frog Leptodactylus laticeps

Page: [411 - 415] Pages: 5

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Abstract

Norepinephrine-stimulated skin secretions from the Sante Fe frog Leptodactylus laticeps contained high concentrations of a peptide, termed laticeptin, with the primary structure Gly-Val-Val-Asp-Ile-Leu-Lys-Gly-Ala-Ala-Lys- Asp-Leu-Ala-Gly-His-Leu-Ala-Thr-Lys-Val-Met-Asn-Lys-Leu.NH2. Laticeptin inhibited the growth of selected Gramnegative bacteria but the lack of activity against Gram-positive bacteria and the very low hemolytic activity is probably a consequence of the weak amphipathicity of the peptide in its a-helical conformation.

Keywords: Antimicrobial peptide, frog skin, leptodactylidae, laticeptin, fallaxin