Author(s): Víctor M. Meseguer, Bristol L. Denlinger and Karel Talavera
Page: [3 - 11] Pages: 9
* (Excluding Mailing and Handling)
Transient Receptor Potential channels are exquisite molecular transducers of multiple physical and chemical stimuli, hence the raising interest to study their relevance to Sensory Biology. Here we discuss a number of aspects of the biophysical and pharmacological properties of TRP channels, which we consider essential for a clear understanding of their sensory function in vivo. By examining concrete examples extracted from recent literature we illustrate that TRP channel research is a field in motion, and that many established dogmas on biophysical properties, drug specificity and physiological role are continuously reshaped, and sometimes even dismantled.
Keywords: TRPV1, TRPA1, TRPM8, sensory neuron, chemosensation, drug specificity, TRP Channels, Transient Receptor Potential channels, Sensory Biology, somatosensation, visceral nociception, neurogenic inflammation, complex endogenous modulation, TRPs in certain, CHEMOSENSORS, methyl salicylate, MO- or cinnamaldehyde- sensitive, menthol-sensitive neurons, TRPA1 modulators, TRPA1 activator MO, TRPV3 2, –, aminoethoxydiphenyl borate, cinnamaldehyde, jugular ganglion neurons, TRPA1 inhibitor HC-030031, nicotine, acetyl choline receptors, nAChRs, photometry, capsaicin, neuro-inflammatory response, alpha-hydroxy-sanshool, TRP-expressing neurons possess, clotrimazole, high voltage-activated Ca2+, GABA, lidocaine, propofol, isofluorane, desfluorane, 1,4-dihydropyridines, nifedipine, nimodipine, nicardipine, nitrendipine, Quinine, TRPA1 activator cinnamaldehyde, Patch-Clamp Experiments, NMDG+, phosphatidylinositol-4,5-biphosphate, bradykinin, nerve growth factor, PIP2-independent
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CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59850559 and j.to_ip >=59850559 )) and ((j.from_date <= 1744718537 and j.to_date >= 1744718537 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 17970)| Backtrace |
|
select * from `article` where `first_page` < '3' and is_uploaded = 1 and issue_id = 3806 order by cast(first_page as SIGNED) desc limit 1| Bindings |
|
| Backtrace |
|
select * from `article` where `last_page` > '11' and is_uploaded = 1 and issue_id = 3806 order by cast(first_page as SIGNED) asc limit 1| Bindings |
|
| Backtrace |
|
select `language_id` from `multilanguage` where `short_code` = 'en'| Bindings |
|
| Backtrace |
|
select `source_lang_label`, `target_lang_label` from `multilanguage_labels` where `target_lang_id` = 1| Bindings |
|
| Backtrace |
|
select `id` from `multilanguage_article` where `article_id` = 17970 limit 1| Bindings |
|
| Backtrace |
|
select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 30 and `b`.`banner_from_date` <= 1744718537 and `b`.`banner_to_date` >= 1744718537 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc| Bindings |
|
| Backtrace |
|
select count(*) as aggregate from `uc_cart_products` where cart_id='fdcdf52df1f72236e177a6a5ffd41aae'| Backtrace |
|
200
[]
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