Abstract

Electrochemical redox compounds, which can interact or bind with different affinities to single and double stranded DNA and thus are referred to as electrochemical hybridization indicators, represent a powerful and, along with this, simple tool for electrochemical genetic analysis. In this paper, general tendencies and recent advances in this field, including the modes of DNA-redox indicators interactions, approaches for their electrochemical analysis, and applications in electrochemical DNA assays are overviewed. This is a critical mini-review with 122 references.

Keywords: Electrochemical biosensors, DNA hybridization, Genosensors, Electrochemical redox indicators, Intercalator, Methylene blue, electrochemical genetic analysis, piezoelectric, SPR devices, redox active compounds, alkanethiol linker, ethidium bromide, acridine derivatives, thracyclines, phenothiazines, metalointercalator, GROOVE-BINDING REDOX INDICATORS, Hoecht 33258, Metalointercalators, Helicobacter pylori, Anthraquinone, Organic Intercalators, daunomycin, benzyl viologen, viologen dimer, mercaptohexyl, phenothiazine dye