Author(s): Oleg Y. Sokolov, Natalya V. Kost, Yurii A. Zolotarev, Ekaterina N. Ryukert and Andrey A. Zozulya
Page: [169 - 170] Pages: 2
* (Excluding Mailing and Handling)
Using radio-receptor analysis, it has been demonstrated that human ε-casomorphin-7 (Tyr-Pro-Phe-Val- Glu-Pro-Ile) displaces 3H-spiperone from 5-HT2-receptors of rat brain frontal cortex. IC50 of human β-casomorphin-7 was 8 μM. These data suggest that one of the mechanisms of neurotropic action of β-casomorphin-7 is might be associated with its influence on the serotoninergic system.
Keywords: Human β-Casomorphin-7, 5-HT2-receptors, spiperone
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