Abstract

This review focuses on the application and implication of CEC for natural product analysis, with special emphasis on reports published after 2005. The basic concepts and principles of CEC are outlined, and the techniques advantages and disadvantages are discussed in context with the available stationary phase format. Special attention is given to the application of packed beds and monolithic formats of CEC with both silica-based and in situ formed polymeric stationary phases. The most promising applicative platforms are presented and their potential for natural product analysis is discussed.

Keywords: CEC, column technology, natural products, applications, review, monolithic formats, silica-based, electrokinetic phenomena, liquid chromatography, electroosmotic flow, high performance liquid chromatography (HPLC), microscale analysis technique, hybrid technique, electrical double layer (EDL), copolymerization, re-optimization, mass transfer properties, post-functionalization, photoinitiation, Organic acrylic polymer monoliths, open tubular column, styrenes, methacrylates, surface chemistry, organic polymer monolith, alkylation, gradient p-CEC, Rhizoma Coptidis, sol-gel process, Coumarins, Angelica dahurica, Flavonoids, Polyphenols, Lignans, Triterpenes and Steroids, sitosterol, campesterol, Xanthones, Fingerprinting, background electrolyte, ethylene dimethacrylate, lauryl methacrylate