Abstract

Efforts have been made to understand the underlying mechanism and stereochemistry for the observed enantio- and diastereoselectivities in various chiral amine catalyzed Mannich reactions with special reference to proline and its analogous derivatives. Substrate scope in Mannich reaction tunable by structural modification in acceptor and donor components, recent examples, developments, and applications are discussed.

Keywords: Asymmetric organocatalysis, mannich reaction, stereoselective synthesis, absolute configuration, proline, organocatalysis, reaction, stereoselective, absolute, amino-carbonyl, acyclic chiral amines, anti-selectivity, hydroxyketones, amination, oxidation, aldol reactions, (PMP), (E)-aldimine, L-proline, syn-adduct, enantioselectivity, N-Boc-imines, enantiomer, acetaldehyde, drug intermediates, chiral amino acids, amino acids, anti-(E)-enamine, Proline Deri-vatives, DMSO