Abstract

The intermolecular radical addition to the carbon atom of imine derivatives has received much less attention until recently, although the use of radical reaction in organic synthesis has continued to increase. This review highlights the intermolecular carbon-carbon bond forming reactions based on carbon radical addition to the carbon-nitrogen double bond. Particularly, the radical reactions of oxime ethers, hydrazones, sulfonylimines, ketimines, and so on are summarized. In this review, strategies for diastereo- and enantioselective radical reactions of imine derivatives are also summarized.

Keywords: Radical, imine, oxime ether, hydrazone, sulfonylimine, amine, diastereoselective, enantioselective