Abstract

Despite ongoing research and new insights into the pathophysiological pathways of neonatal hypoxic-ischemic reperfusion brain injury, effective treatment is not yet available. This review briefly covers the mechanisms of hypoxicischemic reperfusion injury and focuses on promising pharmacological neuroprotective strategies which may become available for clinical use in the near future. Furthermore, the beneficial effects of early intervention and combination therapy with moderate hypothermia are discussed.

Keywords: Newborn, Hypoxia-ischemia, Reperfusion injury of the brain, Neuroprotection